What is AOD-9604?
A fragment of growth hormone researched for fat metabolism.
AOD-9604 is a modified fragment (amino acids 177-191) of human growth hormone. It was researched for obesity but failed to show efficacy in Phase 2b/3 trials. Now marketed in the gray market despite limited evidence.
What the evidence says
The overall evidence grade for AOD-9604 is C (limited — early or preliminary data, mostly mechanistic or animal). Failed clinical trials for obesity. Limited evidence for marketed claims.
Specific findings with supporting evidence:
- Failed Phase 2b/3 obesity trials. Evidence grade A.
Best-supported outcomes:
- Research interest only.
Where marketing outpaces evidence:
- The claim that "Promotes significant fat loss" is not supported by the evidence (grade B).
- The claim that "FDA approved" is not supported by the evidence (grade A).
- Marketing often overstates: Proven fat burner.
- Marketing often overstates: Safe GH alternative.
- Marketing often overstates: Works for weight loss.
Dose and timing
Take it in the morning on an empty stomach. Research compound only.
Who it's for, and who should skip it
Most relevant for:
- Research interest only.
Not appropriate for:
- Anyone seeking proven fat loss therapy.
Safety and cautions
Caution: Failed trials. Did not meet efficacy endpoints in clinical trials. Important: Not FDA approved. Research compound with unproven benefits.
Common mistakes
- Believing marketing over clinical data.
- Expecting significant fat loss.
Myths vs reality
A common misconception: AOD-9604 is a proven fat burner. In reality, it failed clinical trials for obesity.
How it interacts with other compounds
- AOD-9604 works well alongside fragment 176 191 — similar GH fragment concept.
Questions people ask
Why did AOD-9604 fail trials? It did not show statistically significant fat loss compared to placebo.
Editorial note
This guide summarizes the published evidence on AOD-9604. It is educational content, not medical advice. Confirm with your clinician if you take prescription medications or manage a chronic condition.