What is Follistatin-344?
Myostatin inhibitor. Extreme use only. Significant risks.
Follistatin is a protein that inhibits myostatin, theoretically allowing increased muscle growth. Follistatin-344 is a synthetic version used in extreme bodybuilding. Significant safety concerns and unknowns.
What the evidence says
The overall evidence grade for Follistatin-344 is C (limited — early or preliminary data, mostly mechanistic or animal). Known mechanism but extreme experimental use with safety concerns.
Specific findings with supporting evidence:
- Inhibits myostatin. Evidence grade B.
- Used in extreme bodybuilding. Evidence grade B.
Best-supported outcomes:
- Research interest only.
Where marketing outpaces evidence:
- The claim that "Safe for human use" is not supported by the evidence (grade C).
- Marketing often overstates: Massive muscle gains.
- Marketing often overstates: Safe myostatin inhibition.
Dose and timing
Take it in the morning. Extreme experimental use only.
Who it's for, and who should skip it
Most relevant for:
- Research interest only.
Not appropriate for:
- Most people - extreme risks.
Safety and cautions
Important: Unknown safety. Long-term effects of myostatin inhibition unknown. Important: Cardiac concerns. Heart is also muscle; effects unknown. Important: Extreme compound. Used only in extreme bodybuilding circles.
Common mistakes
- Using for casual muscle building.
- Ignoring unknown risks.
Myths vs reality
A common misconception: Follistatin is safe for muscle building. In reality, long-term effects of myostatin inhibition are unknown.
Questions people ask
Why is myostatin inhibition risky? The heart is also muscle; effects of systemic myostatin inhibition are unknown.
Editorial note
This guide summarizes the published evidence on Follistatin-344. It is educational content, not medical advice. Confirm with your clinician if you take prescription medications or manage a chronic condition.