What is LL-37?
Antimicrobial peptide with immune research interest.
LL-37 is a human cathelicidin antimicrobial peptide involved in innate immunity. Research explores antimicrobial and wound healing effects. Highly experimental for therapeutic use.
What the evidence says
The overall evidence grade for LL-37 is C (limited — early or preliminary data, mostly mechanistic or animal). Natural immune peptide but therapeutic use is experimental.
Specific findings with supporting evidence:
- Natural antimicrobial peptide. Evidence grade A.
Best-supported outcomes:
- Research interest only.
Where marketing outpaces evidence:
- The claim that "Therapeutic use is well-established" is not supported by the evidence (grade C).
- Marketing often overstates: Natural antibiotic.
- Marketing often overstates: Immune booster.
Dose and timing
Take it in the morning. Research compound only.
Who it's for, and who should skip it
Most relevant for:
- Research interest only.
Not appropriate for:
- Those seeking antimicrobial treatment.
Safety and cautions
Important: Experimental. Therapeutic use not established. Caution: Complex biology. Antimicrobial peptides have complex effects.
Common mistakes
- Using as an antibiotic alternative.
- Expecting simple immune boosting.
Myths vs reality
A common misconception: LL-37 is a natural antibiotic you can supplement. In reality, therapeutic supplementation is experimental.
Questions people ask
If LL-37 is natural, why is it experimental? Natural presence differs from therapeutic administration.
Editorial note
This guide summarizes the published evidence on LL-37. It is educational content, not medical advice. Confirm with your clinician if you take prescription medications or manage a chronic condition.